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Centrifuges
Research Library
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Analytical Bio-Chemistry Laboratories, Inc
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LC-MS/MS and ICP-AES methods were developed and validated for the quantitation of Gadoversetamide (MP-1177) in human urine. For LC-MS/MS, human urine containing MP-1177 and the internal standard, MP-2077, was centrifuged.The supernatant was analyzed directly. For ICP-AES, human urine containing MP-1177 was acidified with HCl and analyzed directly for gadolinium.
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Diteba Research Laboratories Inc.
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How to Create a Valuable Testing Approaches for prtotein-ligand interactions. The non-covalent binding of small molecules, ligands to proteins or proteins to proteins, plays a crucial role in biopharmaceutical research. This interaction can alter the stereochemistry of a protein molecule (a drug candidate) and also could modify its molecular recognition ability and ultimately its bioactivity. ...
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Analytical Bio-Chemistry Laboratories, Inc
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LC-MS analysis of monkey liver microsomal incubations of the drug candidate J867 in the presence of GSH demonstrated a metabolite with a mass corresponding to a glutathionyl conjugate that must be formed via a 2-electron oxidation process.The LC-MS/MS data were consistent with either a phenyl or a C-oximino conjugate. In order to investigate the site of conjugation, the corresponding incubations ...
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Analytical Bio-Chemistry Laboratories, Inc
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A sensitive radioimmunoassay (RIA) method was validated for the determination of octreotide in male rat plasma using reagents provided in the kits by Peninsula Laboratories, Inc. (Belmont, CA). The components provided in the RIA kit were used to validate octreotide in male rat plasma over a concentration range of 80-1280 pg/mL.
Octreotide mimics the action of somatostatin, a naturally ...
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Kronos Science
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Lipids, Lipoproteins, and Cardiovascular Risk Factors
Disparate LDL Phenotypic Classification among 4
Wayne Ensign,1 Nicole Hill,2 and Christopher B. Heward2*
Background: Our study seeks to clarify the extent of differences in analytical results, from a clinical perspec- tive, among 4 leading technologies currently used in clinical reference laboratories for the analysis of LDL subfractions: ...
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