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Chromatography
Research Library
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Kronos Science
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Oxidative stress is thought to play an important contrib- utory role in the pathogenesis of numerous degenerative or chronic diseases, such as arteriosclerosis [1], cancer [2], tissue injury [3,4], and aging [5–10]. Considerable attention has focused on identifying suitable biomarkers to assess in vivo rates of oxidative damage. Candidate biomarkers can be classied into three major groups: ...
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Kronos Science
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The progressive accumulation of unrepaired free radical damage over time is believed to be a major contributor to the aging process [1,2] and to a variety of age-related chronic diseases [3]. Generation of most free radicals is a “side effect” of normal metabolic processes, especially mitochondrial production of reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide, and ...
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Kronos Science
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Of the DNA-derived biomarkers of
oxidative stress, urinary 8-oxo-7,8-dihydro-2 -deoxyguanosine
(8-oxodG) is the most frequently measured.
However, there is significant discrepancy between
chromatographic and immunoassay approaches,
and intratechnique agreement among all
available chromatography-based assays and ELISAs is
yet to be established. This is a significant obstacle to
their use ...
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SOTAX Corp.
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In the pharmaceutical laboratory, with its various types of automated instruments, some automated devices have become ubiquitous. For example, the auto-injector on a high-performance liquid chromatography system is a tool that most consider indispensable. Fully automated sample preparation and dissolution analysis are common, but their perceived benefit, the ones that justify their purchase, are ...
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Analytical Bio-Chemistry Laboratories, Inc
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Concern regarding extractables and leachables has been increasing over the past few years, as evidenced by regulatory guidance documents [1-3]. One means of qualifying a component as being suitable for use in a drug product is to determine the extraction profile of that component in multiple solvents with polarities similar to and bracketing that of the product vehicle. Any observed extractables ...
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